Alprazolam
Alprazolam (trade name Xanax, available among other generic
names) is a short-acting anxiolytic of the benzodiazepine
class of psychoactive drugs. Alprazolam, like other
benzodiazepines, binds to specific sites on the GABAA
gamma-amino-butyric acid receptor. Alprazolam is commonly used and FDA approved for the
medical treatment of panic disorder, and anxiety
disorders, such as generalized anxiety disorder (GAD) or social anxiety disorder (SAD). Alprazolam
is available for oral administration in compressed tablet (CT) and extended-release
capsule (XR) formulations. Alprazolam possesses
anxiolytic,
sedative,
hypnotic,
skeletal muscle relaxant, anticonvulsant,
and amnestic
properties.
Systematic (IUPAC) name
8-chloro-1-methyl-6-phenyl-4H-
[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Clinical data
Trade names
: Xanax
AHFS/Drugs.com
: monograph
MedlinePlus
: a684001
Pregnancy cat. : D (US)
Legal status : POM
(UK)
Schedule IV (US)
Routes Oral
Pharmacokinetic data
Bioavailability
: 80–90%
Metabolism
: Hepatic,
via Cytochrome P450 3A4
Half-life : Immediate release: 11.2
hours,
Extended release: 10.7–15.8 hours
Extended release: 10.7–15.8 hours
Identifiers
CAS number : 28981-97-7
PubChem
: CID 2118
DrugBank
: DB00404
ChemSpider
: 2034
UNII : YU55MQ3IZY
KEGG : D00225
ChEBI : CHEBI:2611
ChEMBL : CHEMBL661
Chemical data
Mol. mass
: 308.765
SMILES
: ClC1=CC2=C(C=C1)N3C(C)=NN=C3CN=C2C4=CC=CC=C4
InChI : InChI=1S/C17H13ClN4
/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16
/h2-9H,10H2,1H3
Key:VREFGVBLTWBCJP-UHFFFAOYSA-N
Key:VREFGVBLTWBCJP-UHFFFAOYSA-N
Source : http://en.wikipedia.org/wiki/Xanax
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