Nitrazepam
is a type of benzodiazepine drug and is marketed in English-speaking countries
under the following brand names: Alodorm, Arem, Insoma, Mogadon, Nitrados,
Nitrazadon, Ormodon, Paxadorm, Remnos, and Somnite.[2] It is a hypnotic drug
used in the treatment of moderate to severe insomnia which has sedative and
motor impairing properties,[3] as well as anxiolytic, amnestic, anticonvulsant,
and skeletal muscle relaxant properties. Nitrazepam is available in 5 mg and 10
mg tablets. In the Netherlands, Australia, Israel, and the United Kingdom it is
only available in 5 mg tablets. In Denmark it is available as 2.5 mg and 5 mg
tablets under the name Pacisyn.
Systematic
(IUPAC) name
9-nitro-6-phenyl-2,5-diazabicyclo[5.4.0]undeca-
5,8,10,12-tetraen-3-one
Clinical data
Trade names : Alodorm, Arem, Insoma,
Mogadon, Nitrados, Nitrazadon, Ormodon, Paxadorm, Remnos, and Somnite
AHFS/Drugs.com : International Drug Names
Pregnancy cat. : D (AU) D (US)
Legal status : Schedule IV
(International)
Routes :
Oral
Pharmacokinetic
data
Bioavailability : 53-94%
Metabolism : Hepatic
Half-life : 16-38 hours
Excretion : Renal
Identifiers
CAS number : 146-22-5
ATC code : N05CD02
PubChem : CID 4506
DrugBank : DB01595
ChemSpider : 4350
UNII : 9CLV70W7HS
KEGG : D00531
ChEMBL : CHEMBL13209
Chemical data
Formula : C15H11N3O3
Mol. Mass : 218.3 g/mol
SMILES : [O-][N+]
(C1=CC2=C(C=C1)NC(CN=C2C3=CC=CC=C3)=O)=O
InChI : InChI=1S/C15H11N3O3
/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14
/h1-8H,9H2,(H,17,19)
TRIHEXYPHENIDYL
Trihexyphenidyl
(Artane, Apo-Trihex), also known as benzhexol, is an antiparkinsonian agent
of the antimuscarinic class. It has been in clinical usage for decades. The
drug is available as the hydrochloride salt.
Systematic
(IUPAC) name
(RS)-1-cyclohexyl-1-phenyl-
3-(1-piperidyl)propan-1-ol
Clinical data
AHFS/Drugs.com : monograph
MedlinePlus : a682160
Pregnancy cat. : C US
Legal status : Rx-Only (US)
Routes : Oral, as tablet or elixir
Pharmacokinetic
data
Half-life : 3.3-4.1 hours
Identifiers
CAS number : 144-11-6
ATC code : N04AA01
PubChem : CID 5572
DrugBank : DB00376
ChemSpider : 5371
UNII : 6RC5V8B7PO
KEGG : D08638
ChEMBL : CHEMBL1490
Chemical data
Formula : C20H31NO
Mol. Mass : 301.466 g/mol
SMILES : OC(c1ccccc1)(CCN2CCCCC2)C3CCCCC3
InChI : InChI=1S/C20H31NO
/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21
/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
Key:HWHLPVGTWGOCJO-UHFFFAOYSA-N
Dextromethorphan
Dextromethorphan (DXM or DM) is an
antitussive (cough suppressant) drug. It is one of the active ingredients in
many over-the-counter cold and cough medicines, such as Mucinex DM, Robitussin,
NyQuil, Dimetapp, Vicks, Coricidin, Delsym, and others, including generic
labels. Dextromethorphan has also found other uses in medicine, ranging from
pain relief to psychological applications. It is sold in syrup, tablet, spray,
and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.
Systematic
(IUPAC) name
(+)-3-methoxy-17-methyl-(9α,13α,14α)-morphinan
Clinical data
Trade names : Delsym
AHFS/Drugs.com : monograph
MedlinePlus : a682492
Pregnancy cat. : A (AU) C (US)
Legal status : Pharmacy Only (S2) (AU)
OTC (US)
Routes :
Oral
Pharmacokinetic
data
Bioavailability : 11%
Metabolism : Hepatic (liver) enzymes:
major CYP2D6, minor CYP3A4, and minor CYP3A5
Half-life : 1.4–3.9 hours
Excretion : Renal
Identifiers
CAS number : 125-71-3
ATC code : R05DA09
PubChem : CID 15978238
DrugBank : DB00514
ChemSpider : 13109865
UNII : 7355X3ROTS
KEGG : D03742
ChEMBL : CHEMBL52440
Chemical data
Formula : C18H25NO
Mol. Mass : 271.4 g/mol
SMILES : O(c1ccc3c(c1)[C@@]24[C@@H]([C@H](N(CC2)C)C3)CCCC4)C
InChI : InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18
/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
Key:MKXZASYAUGDDCJ-NJAFHUGGSA-N
Physical data
Melt. Point : 111 °C (232 °F)
